Imaging Biomarkers

The shift in paradigm to precision medicine in imaging.- International initiatives for the promotion of imaging biomarkers.- Introduction to the stepwise development of imaging biomarkers.- Defining the biological basis and clinical question: proof of concept.- Looking for the inter-relationship: proof of mechanism.- Images acquisition: modality and protocol definition.- Images preparation.- Imaging biomarkers analysis.- Imaging biomarkers measurements.- Detecting measurement biases: the proof of principle.- Validating the imaging biomarker: the proof of efficacy and effectiveness.- The final step: Reporting imaging biomarkers results.- Sources of uncertainty: accuracy and precision of the measurements.- Pearls and pitfalls in Gold standards and biological correlation.- Imaging biobanks, big data and population-based imaging biomarkers.- A proposed Imaging Biomarkers analysis platform architecture for integration in clinics.- Use case I: Imaging biomarkers in neurodegenerative disease.- Use case II: Imaging biomarkers in tumors.- Use case III: Imaging biomarkers in thorax and heart.- Use case IV: Imaging biomarkers in musculoskeletal disorders.- Use case V: Imaging biomarkers in diffuse liver disease.

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• Imagiologia médica
• Engenharia biomédica

Biomedical Engineering;Image Processing;Imaging Biomarker Development;Imaging Biomarkers Measurements;Multi-variate analysis;Parametric Images;Quantitative Radiology;Precision Medicine in Imaging;Imaging Biobanks