Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Section 1: Evidence for inflammation-associated depression.- Evidence for inflammation-associated depression.- Role of inflammation in the development of neuropsychiatric symptom domains.- Inflammation-associated comorbidity.- Section 2: Mechanisms of inflammation-associated depression.- Mechanisms of inflammation-associated depression Immune-to-brain communication pathways and cytokines.- Immune-to-brain communication pathways.- Mechanisms of inflammation-associated depression.- Role of the kynurenine metabolism pathway.- Depression in autoimmune diseases.- Stress-induced microglia activation.- Inflammation effects on brain glutamate.- The role of dopamine.- Brain structures implicated in inflammation-associated depression.- Role of kynurenine metabolism pathway.- Suicidality. Section 3: Clinical implications of inflammation-associated depression.- The promise and limitations of anti-inflammatory agents.- Are non-steroidal anti-inflammatory drugs.- Does diet matter?- Role of neuroimunological factors.

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• Neurociências
• Psicologia da saude
• Psiquiatria
• Imunologia

Biological Psychiatry;Depression;Inflammation;Cytokine;Indoleamine 2,3 dioxygenase;Kynurenine;Phenylalanine;Tetrahydrobiopterin;Obesity;Cardiovascular disorders;psychopharmacology