Science and Practice of Lithium Therapy

Section I: Science of Lithium: The Ion : Lithium.- Pharmacokinetics and pharmacodynamics of lithium.- Lithium : neurotransmission and cellular mechanisms pathways underlying neuroprogression in bipolar disorder.- Lithium on gene expression modulation.- Neuroimaging and lithium.- Conclusion: overview of potential mechanisms of action of lithium in bipolar disorder.- Section II: Practice of Lithium Therapy.- Introduction of lithium in Medicine and Psychiatry.- Lithium Response variability.- Lithium Response variability: Pharmacogenomics studies.- Lithium Response variability: Biomarkers.- Lithium in acute and maintenance treatment of bipolar disorders.- Lithium and suicide prevention.- Lithium in Bipolar disorders international guidelines.- Lithium and pregnancy.- Lithium in children and adolescents.- Short and mid-term side effects of lithium.- Lithium, kidneys, renal failure.- Lithium intoxication.- Discontinuation and re-use of lithium.- Conclusion : overview of indications and monitoring of lithium in bipolar disorders.

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• Neurociências
• Psicofarmacologia
• Farmacologia

Bipolar Disorders;Lithium;Lithium Ion;Lithium in Bipolar Disorder;Mood Stabilizer;Neurobiological Pathways;Pharmacodynamics of Lithium;Pharmacokinetics of Lithium;Psychopharmacology;Mania;Depression;Suicide;Neuroprotection;Augmentaton Therapy;Manic-Depressive Illness;pharmacotherapy